منابع مشابه
Protease-dependent uncoating of a complex retrovirus.
Although retrovirus egress and budding have been partly unraveled, little is known about early stages of the replication cycle. In particular, retroviral uncoating, a process during which incoming retroviral cores are altered to allow the integration of the viral genome into host chromosomes, is poorly understood. To get insights into these early events of the retroviral cycle, we have used foa...
متن کاملStructure of the aspartic protease from Rous sarcoma retrovirus refined at 2-A resolution.
The structure of Rous sarcoma virus protease has been solved by multiple isomorphous replacement in the crystal form belonging to space group P3(1)21, with unit-cell parameters a = 88.95 A and c = 78.90 A. The enzyme belongs to the family of aspartic proteases with two identical subunits composing the active homodimer. The noncrystallographic dyad relating these two subunits was identified afte...
متن کاملSusceptibility of the porcine endogenous retrovirus to reverse transcriptase and protease inhibitors.
Porcine xenografts may offer a solution to the shortage of human donor allografts. However, all pigs contain the porcine endogenous retrovirus (PERV), raising concerns regarding the transmission of PERV and the possible development of disease in xenotransplant recipients. We evaluated 11 antiretroviral drugs licensed for human immunodeficiency virus type 1 (HIV-1) therapy for their activities a...
متن کاملCharacterization of the protease of a fish retrovirus, walleye dermal sarcoma virus.
Three fish retroviruses infecting walleyes constitute the recently recognized genus called epsilonretrovirus. The founding member of this group, walleye dermal sarcoma virus (WDSV), induces benign skin tumors in the infected fish and replicates near 4 degrees C. While the viral genomic sequence is known, biochemical characterization of the virus has been limited to the identification of the mat...
متن کاملRetrovirus receptors
The cell surface receptors that act as portals of virus entry into animal cells have become a focus of renewed interest in recent years with the identification of receptor molecules (Wimmer, 1994). Genetic manipulation of receptor genes has enabled the mapping of virus-binding sites and of the normal functions of the receptors. Expression of human receptors in transgenic mice (e.g., for polio v...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1990
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.64.1372